Inicio > Matemáticas y ciencia > Ciencia: cuestiones generales > Valutazione della tossicità della cipermetrina nei topi di laboratorio
Valutazione della tossicità della cipermetrina nei topi di laboratorio

Valutazione della tossicità della cipermetrina nei topi di laboratorio

M. Saiful Islam / Md. Mizanul Hoque

71,42 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2023
Materia
Ciencia: cuestiones generales
ISBN:
9786206987246
71,42 €
IVA incluido
Disponible

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La cipermetrina, un insetticida piretroide sintetico con una neurotossina ad azione rapida noto per causare danni tissutali mediati dai radicali liberi in un’ampia gamma di animali, è stata qui utilizzata nei topi albini da laboratorio Mus musculus L. per valutarne la tossicità in termini di segni comportamentali e clinici, accompagnati da cambiamenti morfometrici, istopatologici ed ematologici negli animali da esperimento. Topi maschi (~20g) hanno ricevuto 0,10mL-0,25mL-1 di peso corporeo di cipermetrina per via intraperitoneale ogni settimana per quattro settimane consecutive. Si sono notate gravi alterazioni istopatologiche, soprattutto nel fegato e nei reni, insieme alla perdita di peso degli organi e alla necrosi di varie parti del corpo. Il profilo ematologico dei topi trattati con cipermetrina ha rivelato una diminuzione statisticamente significativa di RBC, piastrine, emoglobina, neutrofili e basofili, ma un aumento di WBC come linfociti, monociti ed eosinofili. I risultati indicano che la cipermetrina è dannosa per i mammiferi, compresi gli esseri umani; pertanto, è necessario garantire un uso giudizioso di questo insetticida durante l’applicazione nei campi agricoli e negli ambienti domestici.

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