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Valutazione a campione dei fattori di virulenza dell’H. Pylori

Valutazione a campione dei fattori di virulenza dell’H. Pylori

Rogério Tomanini

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786207994236
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Sobre IBD

Secondo studi condotti in diversi Paesi, l’elevata incidenza dello sviluppo di malattie dell’apparato digerente umano è direttamente correlata all’infezione da parte del batterio Helicobacter pylori, che provoca un processo infiammatorio nella mucosa gastrica seguito da un aumento della produzione di citochine, dando origine a diverse patologie quali: dispepsia senza ulcera, esofagite da reflusso, gastrite erosiva, gastrite cronica, ulcera peptica gastrica, ulcera peptica duodenale e cancro gastrico. In questo processo si generano radicali liberi di ossigeno e/o azoto che causano danni ossidativi al DNA. È stato riscontrato che i ceppi più virulenti producono un danno maggiore al DNA delle cellule gastriche, oltre a indurre l’apoptosi e a stimolare la moltiplicazione cellulare, producendo così alterazioni del sistema di turnover. In questo studio, i fattori di virulenza cagA e vacA m1/m2-s1/s2 dell’Helicobacter pylori sono stati valutati in campioni provenienti da 45 pazienti dell’Ospedale Universitario São Francisco di Bragança Paulista / SP, da giugno 2011 a gennaio 2012 ed elaborati presso l’UNIFAG (Unità Integrata di Farmacologia e Gastroenterologia dell’Università di São Francisco).

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