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Transdermales Pflaster für ein blutdrucksenkendes Medikament

Transdermales Pflaster für ein blutdrucksenkendes Medikament

Deepak Kumar / Pavan Kumar Yadav / Preeti Pal

61,55 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786207915217
61,55 €
IVA incluido
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Sobre IBD

Das Szenario der Forschung war die Entwicklung eines Polymermatrix-Diffusionskontrollierten transdermalen Wirkstoffabgabesystems, das den Wirkstoff Telmisartan mit einem unterschiedlichen Verhältnis von hydrophilem (HPMC) und lipophilem (EC, Eudragit RS 100) Polymersystem durch Lösungsmittelgießtechnik auf Aluminiumfolie enthält, wobei 30% w/v Dibutylphthalat des Polymergewichts als Weichmacher und 20% w/v, 30% w/v Dimethylsulfoxid (Polymergewicht) als Permeationsverstärker für die transdermale Wirkstofffreisetzung verwendet wurden. Insgesamt neun Formulierungen wurden unter Verwendung desselben Arzneimittels und verschiedener Polymeranteile entwickelt. Alle transdermalen Pflaster wurden physikochemisch bewertet: Dicke, Gewichtsvariation, prozentuale Feuchtigkeitsaufnahme, prozentualer Feuchtigkeitsverlust, Faltfestigkeit, Flachheit, Wirkstoffgehalt und prozentuale Wirkstofffreisetzung. . Die In-vitro-Permeationsstudie wurde mit Diffusionszellen durchgeführt. Die maximale prozentuale Wirkstofffreisetzung in vitro wurde bis zu 48 Stunden mit der Formulierung F8 beobachtet, die HPMC: EC: Eudragit RS 100 im Verhältnis (5:0:1) enthält.

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