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Tabletki szybko rozpuszczalne przeciwcukrzycowe

Tabletki szybko rozpuszczalne przeciwcukrzycowe

Anupam Singh Bhadouriya / Pramod Kumar Biswal

98,59 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786630295719
98,59 €
IVA incluido
Disponible

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Sobre IBD

Badania nad preparatami koncentrują się na bezpieczeństwie, skuteczności i szybkim początku działania istniejącej cząsteczki leku dzięki nowatorskim koncepcjom podawania leków. Chlorowodorek metforminy jest doustnym lekiem przeciwcukrzycowym z grupy biguanidów, stosowanym w leczeniu cukrzycy insulinoniezależnej (typu 2). Tabletki rozpuszczające się w jamie ustnej zawierające chlorowodorek metforminy przygotowano metodą bezpośredniego prasowania. W ramach niniejszego badania opracowano około dziewięciu preparatów w oparciu o kombinację dwóch superrozpadaczy. Jako superrozpadacze zastosowano kroskarmelozę sodową, krospowidon oraz glikolan sodowy skrobi. Przygotowane partie tabletek poddano ocenie pod kątem zmienności masy, twardości, kruchości, czasu zwilżania, czasu dyspersji in vitro, zawartości substancji czynnej oraz w badaniach rozpuszczalności in vitro. Preparat zawierający połączenie kroskarmelozy sodowej i glikolanu skrobi sodowej wykazał szybki czas dyspersji in vitro w porównaniu z innymi preparatami. Zoptymalizowany preparat uległ dyspersji w ciągu 28 sekund. Wykazał on również wyższy współczynnik absorpcji wody, a 98,37% substancji czynnej uległo uwolnieniu w ciągu 30 minut.

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