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Synthèse et évaluation de nouveaux dérivés du carbazole

Synthèse et évaluation de nouveaux dérivés du carbazole

Archita Tiwari / Bharat Mishra / Sujeet Gupta

54,12 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Química
ISBN:
9786207951574
54,12 €
IVA incluido
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Sobre IBD

Une nouvelle série de dérivés carbazoles substitués a été synthétisée. Dans la première étape, le 2-Chloro-9-H-carbazole-3-carbaldéhyde est formé par la réaction de vielsmeier-Hack en présence de DMF et de POCl3. Le produit intermédiaire formé à l’aide de la réaction de Vielsmeier est ensuite traité avec une amine substituée différente pour obtenir un nouveau dérivé de carbazole fusionné avec l’amine substituée. La structure du dérivé carbazole substitué a été identifiée par chromatographie sur couche mince, FT-IR et 1H NMR. À l’aide du modèle de l’électrochoc maximal (MES), la puissance des composés synthétisés a été déterminée sur la base de leur réduction des convulsions à différents intervalles de temps. Parmi tous les composés synthétisés, le composé 4e a montré l’activité anticonvulsive maximale. Les composés 4c et 4f ont également montré une meilleure activité anticonvulsive.

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