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Síntese e Avaliação de Novos Derivados de Carbazol

Síntese e Avaliação de Novos Derivados de Carbazol

Archita Tiwari / Bharat Mishra / Sujeet Gupta

54,12 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Química
ISBN:
9786207951598
54,12 €
IVA incluido
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Sobre IBD

Foi sintetizada uma nova série de derivados de carbazol substituídos. No primeiro passo, o 2-Cloro-9-H-carbazole-3-carbaldeído formou-se através da reação de vielsmeier-Hack na presença de DMF e POCl3. O produto intermédio formado com a ajuda da reação de vielsmeier é posteriormente tratado com uma amina substituída diferente para obter um novo derivado de carbazole fundido com a amina substituída. A estrutura do derivado de carbazole substituído foi identificada por cromatografia de camada fina, FT-IR e 1H NMR. Com a ajuda do modelo de eletrochoque máximo (MES), a potência dos compostos sintetizados foi determinada com base na sua redução de convulsões em diferentes intervalos de tempo. Entre todos os compostos sintetizados, o composto 4e apresentou a atividade anticonvulsiva máxima. O composto 4c e o composto 4f também apresentaram uma melhor atividade anticonvulsiva.

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