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Skuteczność receptorów opioidowych w warunkach normalnych i patologicznych

Skuteczność receptorów opioidowych w warunkach normalnych i patologicznych

Baled Ibrahim N Khalefa

89,45 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208982546
89,45 €
IVA incluido
Disponible

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Wzdłuż ścieżki bólowej, tj. od obwodowego neuronu czuciowego przez rdzeń kręgowy do wzgórza i kory czuciowej, receptory opioidowe mu (MOR) są dostępne do modulacji napływających bodźców bólowych. W niniejszej książce zbadano względny wpływ MOR na ogólnoustrojowe działanie przeciwbólowe agonistów MOR na poziomie obwodowego neuronu czuciowego, rdzenia kręgowego i mózgu. Ponadto, ponieważ wcześniejsze badania sugerowały, że receptory opioidowe neuronów czuciowych mogą różnić się pod względem liczby, sprzężenia z białkiem G i skuteczności w zależności od obecności stanu normalnego lub patologicznego (np. nowotwór, stan zapalny), w niniejszej książce zbadano podstawowe mechanizmy zmniejszonej wrażliwości na opioidy i przeanalizowano możliwe podejścia terapeutyczne w modelu zwierzęcym bólu neuropatycznego wywołanego streptozotocyną.

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