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Eficácia do recetor opióide em condições normais e patológicas

Eficácia do recetor opióide em condições normais e patológicas

Baled Ibrahim N Khalefa

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208982591
89,45 €
IVA incluido
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Sobre IBD

Ao longo da via da dor, ou seja, desde o neurónio sensorial periférico, passando pela medula espinhal, até ao tálamo e ao córtex sensorial, os recetores opioides mu (MOR) estão acessíveis para a modulação dos estímulos dolorosos recebidos. Neste livro, foram examinadas as contribuições relativas dos MOR para os efeitos antinociceptivos sistémicos dos agonistas dos MOR ao nível do neurónio sensorial periférico, da medula espinhal e do cérebro. Além disso, uma vez que trabalhos anteriores sugeriram que os recetores opióides dos neurónios sensoriais podem variar em número, acoplamento da proteína G e eficácia, dependendo da presença de uma condição normal ou patológica (por exemplo, cancro, inflamação), este livro examinou os mecanismos subjacentes a uma resposta opióide reduzida e explorou possíveis abordagens terapêuticas no modelo animal de dor neuropática diabética induzida por estreptozotocina.

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Otros libros del autor

  • Efficacité des récepteurs opioïdes dans des conditions normales et pathologiques
    Baled Ibrahim N Khalefa
    Le long de la voie de la douleur, c’est-à-dire depuis les neurones sensoriels périphériques jusqu’au thalamus et au cortex sensoriel en passant par la moelle épinière, les récepteurs opioïdes mu (MOR) peuvent moduler les stimuli douloureux entrants. Cet ouvrage examine les contributions relatives des MOR aux effets antinociceptifs systémiques des agonistes MOR au niveau des neu...
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  • Efficacia dei recettori oppioidi in condizioni normali e patologiche
    Baled Ibrahim N Khalefa
    Lungo la via del dolore, ovvero dal neurone sensoriale periferico attraverso il midollo spinale fino al talamo e alla corteccia sensoriale, i recettori mu-oppioidi (MOR) sono accessibili per la modulazione degli stimoli dolorosi in arrivo. In questo libro sono stati esaminati i contributi relativi dei MOR agli effetti antinocicettivi sistemici degli agonisti dei MOR a livello d...
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  • Skuteczność receptorów opioidowych w warunkach normalnych i patologicznych
    Baled Ibrahim N Khalefa
    Wzdłuż ścieżki bólowej, tj. od obwodowego neuronu czuciowego przez rdzeń kręgowy do wzgórza i kory czuciowej, receptory opioidowe mu (MOR) są dostępne do modulacji napływających bodźców bólowych. W niniejszej książce zbadano względny wpływ MOR na ogólnoustrojowe działanie przeciwbólowe agonistów MOR na poziomie obwodowego neuronu czuciowego, rdzenia kręgowego i mózgu. Ponadto, ...
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    Entlang des Schmerzbahns, d. h. vom peripheren sensorischen Neuron über das Rückenmark zum Thalamus und zum sensorischen Kortex, stehen Mu-Opioidrezeptoren (MOR) für die Modulation eingehender Schmerzreize zur Verfügung. In diesem Buch wurden die relativen Beiträge von MOR zu den systemischen antinozizeptiven Wirkungen von MOR-Agonisten auf der Ebene des peripheren sensorischen...
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