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Simvastatin-Feststoffdispersion, hergestellt mittels Mikrowellenfusionsverfahren

Simvastatin-Feststoffdispersion, hergestellt mittels Mikrowellenfusionsverfahren

B.N. Patel / D.M. Patel / Haresh Chaudhary

102,77 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209969720
102,77 €
IVA incluido
Disponible

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Sobre IBD

Simvastatin, eine kristalline Substanz, ist ein weit verbreitetes Medikament zur Behandlung von Hypercholesterinämie. Es handelt sich um ein Medikament der BCS-Klasse II mit geringer Wasserlöslichkeit (0,76 mg/l), das ein schlechtes Auflösungsverhalten und eine geringe orale Bioverfügbarkeit (5 %) aufweist. Ziel dieser Studie war es, die vielversprechende Technik der Mikrowellenfusion zur Herstellung von lösungsmittelfreien festen Dispersionen anzuwenden und die Löslichkeit sowie die Auflösungsrate von Simvastatin durch eine feste Dispersion zu verbessern. Ziel dieser Studie war es, die vielversprechende Technik der Mikrowellenfusion zur Herstellung lösungsmittelfreier fester Dispersionen anzuwenden und die Löslichkeit sowie die Auflösungsgeschwindigkeit von Simvastatin durch eine feste Dispersion zu verbessern.

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