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Dispersion solide de simvastatine préparée par la technique de fusion par micro-ondes

Dispersion solide de simvastatine préparée par la technique de fusion par micro-ondes

B.N. Patel / D.M. Patel / Haresh Chaudhary

101,46 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209974847
101,46 €
IVA incluido
Disponible

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Sobre IBD

La simvastatine, une substance cristalline, est un médicament largement utilisé dans le traitement de l’hypercholestérolémie. Il s’agit d’un médicament de classe II selon la classification BCS, caractérisé par une faible solubilité dans l’eau (0,76 mg/L), un profil de dissolution médiocre et une faible biodisponibilité orale (5 %). L’objectif de cette étude était d’appliquer la technique prometteuse de la fusion par micro-ondes pour la préparation de dispersions solides sans solvant de simvastatine, une substance cristalline largement utilisée dans le traitement de l’hypercholestérolémie. Il s’agit d’un médicament de classe II selon la classification BCS, présentant une faible solubilité dans l’eau (0,76 mg/L), un profil de dissolution médiocre et une faible biodisponibilité orale (5 %). L’objectif de cette étude était d’appliquer la technique prometteuse de la fusion par micro-ondes pour la préparation de dispersions solides sans solvant et d’améliorer la solubilité et la vitesse de dissolution de la simvastatine grâce à une dispersion solide.

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