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Przeciwzapalne działanie polisacharydu z algi Hypnea musciformis

Przeciwzapalne działanie polisacharydu z algi Hypnea musciformis

André Luiz Reis Barbosa / Tarcisio Vieira de Brito

52,55 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786206813224
52,55 €
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Siarczanowane polisacharydy ekstrahowane z alg mają istotne właściwości farmakologiczne. Dlatego celem tego badania było scharakteryzowanie siarczanowanego polisacharydu (PLS) z alg Hypnea musciformis i ocena jego ochronnego wpływu na zapalenie jelita grubego wywołane kwasem trinitrobenzenosulfonowym u szczurów. Siarczanowany polisacharyd ma wysoką masę cząsteczkową (1,24 x 105 g.mol-1). Szczurom podawano PLS doustnie (10, 30 i 60 mg/kg, p.o.). Szczury zabito trzeciego dnia, wycięto część dystalnej okrężnicy (5 cm) i oceniono wyniki makroskopowe oraz mokrą masę. Próbki jelita zostały następnie wykorzystane do oceny histologicznej i ilościowego oznaczenia glutationu, kwasu malonylodehydowego, mieloperoksydazy, azotanów/azotynów i cytokin. Nasze wyniki pokazują, że PLS zmniejszył zapalenie jelita grubego i wszystkie analizowane parametry biochemiczne. W związku z tym stwierdzamy, że PLS wyekstrahowany z wodorostów H. musciformis zmniejsza zapalenie okrężnicy w modelu zwierzęcym i może mieć obiecujące zastosowanie w chorobach zapalnych jelit.

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