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Prospezione di Nothapodytes nimmoniana (J.Graham) Mabberley

Prospezione di Nothapodytes nimmoniana (J.Graham) Mabberley

P. E. Rajasekharan / V. K. Abdul Kareem

45,22 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Botánica y ciencias de las plantas
ISBN:
9786209324833
45,22 €
IVA incluido
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La Nothapodytes nimmoniana Graham è un’importante pianta medicinale indiana ricca di camptotecina, un alcaloide chinolinico considerato il farmaco antitumorale più promettente del XXI secolo. La camptotecina (CPT), un alcaloide indolico monoterpenico, è uno dei farmaci antitumorali più promettenti del XXI secolo. Sebbene la CPT sia stata segnalata in diverse specie, la concentrazione più elevata è stata riscontrata nella Nothapodytes nimmoniana, un piccolo albero diffuso nei Ghati occidentali dell’India. Recentemente sono stati avviati alcuni progetti per la conservazione e la produzione in vitro della CPT, l’identificazione di individui ad alto rendimento e la profilazione molecolare. In questo articolo vengono trattati la biologia riproduttiva e la distribuzione del comportamento riproduttivo, la chimica, la struttura e le proprietà della CPT, l’estrazione e l’accumulo della CPT, la biosintesi, la coevoluzione e la conservazione di questa specie. Descriviamo brevemente lo stato generale della N. nimmoniana come fonte di CPT e discutiamo la possibilità di un intervento biotecnologico per una maggiore produzione di CPT senza il raccolto distruttivo della popolazione naturale.

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