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Prognozowanie właściwości molekularnych i synteza analogów oksadiazolu

Prognozowanie właściwości molekularnych i synteza analogów oksadiazolu

Mohamed Jawed Ahsan / Piush Sharma / Rakesh Sharma

60,13 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209359392
60,13 €
IVA incluido
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Seria 11 analogów oksadiazolu została poddana prognozowaniu właściwości molekularnych i podobieństwa do leków za pomocą oprogramowania Molinspiration i MolSoft, a także parametrów lipofilowości i rozpuszczalności za pomocą programu ALOGPS 2.1. Związki zgodne z „zasadą pięciu' Lipinskiego zostały zsyntetyzowane w celu przeprowadzenia badań przeciwbakteryjnych jako leki/związki wiodące dostępne w postaci doustnej. Ponadto struktura zsyntetyzowanych związków została potwierdzona analizami spektralnymi (IR, NMR i masowymi), a związki (4a-k) zostały ocenione pod kątem działania przeciwbakteryjnego i przeciwgrzybiczego zgodnie ze standardową procedurą. Stwierdzono, że N-(2-metylofenylo)-5-(4-chlorofenylo)-1,3,4-oksadiazol-2-amina, 4c wykazuje maksymalną aktywność przeciwbakteryjną, natomiast N-(2-metylofenylo)-5-(4-hydroksyfenylo)-1,3,4-oksadiazol-2-amina, 4d wykazuje maksymalną aktywność przeciwgrzybiczą.

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