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Previsão das propriedades moleculares e síntese de análogos de oxadiazol

Previsão das propriedades moleculares e síntese de análogos de oxadiazol

Mohamed Jawed Ahsan / Piush Sharma / Rakesh Sharma

60,13 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209372193
60,13 €
IVA incluido
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Uma série de 11 análogos de oxadiazol foi submetida à previsão das propriedades moleculares e semelhança com fármacos pelos softwares Molinspiration e MolSoft, e aos parâmetros de lipofilia e solubilidade pelo programa ALOGPS 2.1. Os compostos seguiram a Regra dos cinco de Lipinski e foram sintetizados para triagem antimicrobiana como fármacos/chumbo biodisponíveis por via oral. Além disso, a estrutura dos compostos sintetizados foi confirmada por análises espectrais (IR, NMR e massa) e os compostos (4a-k) foram avaliados quanto às suas atividades antibacterianas e antifúngicas, de acordo com o protocolo padrão. Verificou-se que a N-(2-metilfenil)-5-(4-clorofenil)-1,3,4-oxadiazol-2-amina, 4c, apresentava a máxima atividade antibacteriana, enquanto a N-(2-metilfenil)-5-(4-hidroxifenil)-1,3,4-oxadiazol-2-amina, 4d, apresentava a máxima atividade antifúngica.

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