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Polimorfismos do gene da citocina em pacientes iraquianos com leishmaniose visceral

Polimorfismos do gene da citocina em pacientes iraquianos com leishmaniose visceral

Ali Ad’hiah / Ekhlas Idan / Zahra’a Ahmad

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786202497701
68,82 €
IVA incluido
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Sobre IBD

A leishmaniose visceral (LV) é uma doença zoonótica sistémica grave causada pelo protozoário Leishmania donovani ou L. infantum, na qual as citocinas desempenham um papel importante na sua patogénese. Estas citocinas estão sob controlo genético e os seus polimorfismos genéticos têm sido sugeridos como tendo um papel funcional na regulação da expressão dos genes das citocinas. Portanto, o presente estudo determinou os níveis séricos de IFN-γ, IL-2, IL-10 e IL-12 e os polimorfismos genéticos de 11 genes de citocinas e receptores de citocinas (IL1A, IL1B, IL2, IL4, IL4R, IL6, IL10, IL12B, TNF, IFNG e TGFB1) em pacientes com LV por meio do ensaio ELISA e do método de PCR com primers específicos para sequências. O impacto do polimorfismo genético nos níveis séricos de IFN-γ, IL-2, IL-10 e IL-12 também foi avaliado. Estas avaliações foram realizadas em crianças árabes iraquianas com LV.

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