Inicio > Matemáticas y ciencia > Biologia, ciencias de la vida > Polimorfismi dei geni delle citochine nei pazienti iracheni affetti da leishmaniosi viscerale
Polimorfismi dei geni delle citochine nei pazienti iracheni affetti da leishmaniosi viscerale

Polimorfismi dei geni delle citochine nei pazienti iracheni affetti da leishmaniosi viscerale

Ali Ad’hiah / Ekhlas Idan / Zahra’a Ahmad

68,81 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786202497718
68,81 €
IVA incluido
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Sobre IBD

La leishmaniosi viscerale (LV) è una grave malattia zoonotica cronica sistemica causata dal protozoo Leishmania donovani o L. infantum, in cui le citochine svolgono un ruolo importante nella patogenesi. Queste citochine sono sotto controllo genetico e i loro polimorfismi genici hanno suggerito di esercitare un ruolo funzionale nella regolazione dell’espressione genica delle citochine. Pertanto, il presente studio ha determinato i livelli sierici di IFN-γ, IL-2, IL-10 e IL-12 e i polimorfismi genici di 11 geni delle citochine e dei recettori delle citochine (IL1A, IL1B, IL2, IL4, IL4R, IL6, IL10, IL12B, TNF, IFNG e TGFB1) in pazienti affetti da VL mediante test ELISA e metodo PCR con primer specifici per sequenza. È stato inoltre valutato l’impatto del polimorfismo genico sui livelli sierici di IFN-γ, IL-2, IL-10 e IL-12. Queste valutazioni sono state effettuate su bambini arabi iracheni affetti da LV.

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