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Podejście oparte na projekcie czynnikowym jako narzędzie metodologii optymalizacji

Podejście oparte na projekcie czynnikowym jako narzędzie metodologii optymalizacji

Amita Ahir / Sachin Mali / Suryakant Gaikwad

60,20 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786202423663
60,20 €
IVA incluido
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Sobre IBD

Głównym celem niniejszego badania było opracowanie plastra transdermalnego z wyciągiem z kory Terminaliaarjuna do kontroli systemu dostarczania leków w zaburzeniach CVS. Ekstrakcję kory Terminaliaarjuna przeprowadzono przy użyciu techniki maceracji, natomiast ilościowe oszacowanie kwasu arjunolowego wykonano przy użyciu metody miareczkowania ekstraktu. Wstępne badania fitochemiczne wykazały obecność w ekstrakcie alkaliów, glikozydów nasercowych, garbników, triterpenoidów i saponin. W celu przewidzenia optymalnej skuteczności przygotowanego plastra transdermalnego z Terminaliaarjuna przyjęliśmy podejście oparte na 32 czynnikach. Jako zmienne niezależne wybrano ilość HPMC K100 i Eudragit RL100, a jako zmienną zależną procentowe uwalnianie leku. Badano różne parametry, w tym grubość, płaskość, wchłanianie wilgoci, zawartość wilgoci, wytrzymałość na rozciąganie, zawartość leku i dyfuzję leku.

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