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Approccio fattoriale come strumento di ottimizzazione metodologica

Approccio fattoriale come strumento di ottimizzazione metodologica

Amita Ahir / Sachin Mali / Suryakant Gaikwad

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786202423700
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Sobre IBD

L’obiettivo principale del presente studio era quello di formulare un cerotto transdermico a base di estratto di corteccia di Terminalia ajuna per il controllo del sistema di somministrazione dei farmaci nei disturbi del sistema cardiovascolare. L’estrazione della corteccia di Terminalia ajuna è stata effettuata utilizzando la tecnica di macerazione, mentre la stima quantitativa dell’acido arjunolico è stata effettuata utilizzando il metodo di titolazione dell’estratto. Dal test fitochimico preliminare è emerso che nell’estratto sono presenti alcali, glicosidi cardiaci, tannini, triterpenoidi e saponine. Al fine di prevedere le prestazioni ottimali del cerotto transdermico preparato a base di Terminaliaarjuna, abbiamo adottato un approccio di progettazione fattoriale a 32 fattori. La quantità di HPMC K100 ed Eudragit RL100 è stata selezionata come variabile indipendente e la percentuale di rilascio del farmaco come variabile dipendente. I vari parametri studiati includono spessore, planarità, assorbimento di umidità, contenuto di umidità, resistenza alla trazione, contenuto di farmaco e diffusione del farmaco.

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