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Pentraxina 3 e doença vascular aterosclerótica

Pentraxina 3 e doença vascular aterosclerótica

Eman Youness / Wafaa Wafy

61,10 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Empresa y gestión
ISBN:
9786207741373
61,10 €
IVA incluido
Disponible

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A PTX3 é uma molécula solúvel de reconhecimento de padrões envolvida em processos imunes inatos e respostas inflamatórias. Além disso, regula a angiogénese, influenciando o fornecimento de sangue aos tecidos. Estes resultados oferecem novas perspectivas sobre a patogénese da PTX3 nas doenças cardiovasculares (DCV). De facto, as doenças cardiovasculares múltiplas não são isoladas, mas estão intimamente relacionadas. Por exemplo, a hipertensão a longo prazo pode exacerbar a aterosclerose (AS) e pode eventualmente levar à insuficiência cardíaca (HF). A PTX3 é um biomarcador valioso para a estratificação do risco em várias doenças cardiovasculares, ajudando a prever os resultados. Surgiu como uma proteína crucial de fase aguda associada à inflamação em doenças cardiovasculares, incluindo insuficiência cardíaca, aterosclerose, síndromes coronárias agudas e doenças vasculares periféricas. É importante notar que o valor preditivo da PTX3 parece ser independente de outros factores de risco, incluindo outros marcadores da mesma superfamília, como a PCR. O rápido aumento dos níveis plasmáticos de PTX3 durante eventos cardiovasculares, uma consequência da rápida síntese por vários tipos de células, apoia a noção de que a PTX3 poderia servir como um indicador precoce da ativação de respostas imunitárias e inflamatórias.

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Otros libros del autor

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    PTX3 ist ein lösliches Mustererkennungsmolekül, das an angeborenen Immunprozessen und Entzündungsreaktionen beteiligt ist. Außerdem reguliert es die Angiogenese und beeinflusst damit die Blutversorgung des Gewebes. Diese Erkenntnisse bieten neue Einblicke in die Pathogenese von PTX3 bei kardiovaskulären Erkrankungen (CVDs). In der Tat sind mehrere CVDs nicht isoliert, sondern e...
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