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Pentrassina 3 e malattia vascolare aterosclerotica

Pentrassina 3 e malattia vascolare aterosclerotica

Eman Youness / Wafaa Wafy

61,10 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Empresa y gestión
ISBN:
9786207741304
61,10 €
IVA incluido
Disponible

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PTX3 è una molecola di riconoscimento solubile coinvolta nei processi immunitari innati e nelle risposte infiammatorie. Inoltre, regola l’angiogenesi, influenzando l’apporto di sangue ai tessuti. Questi risultati offrono nuovi spunti di riflessione sulla patogenesi di PTX3 nelle malattie cardiovascolari (CVD). Infatti, le CVD multiple non sono isolate ma strettamente correlate. Per esempio, l’ipertensione a lungo termine può esacerbare l’aterosclerosi (AS) e può infine portare all’insufficienza cardiaca (HF). PTX3 funge da prezioso biomarcatore per la stratificazione del rischio in varie CVD, contribuendo alla previsione degli esiti. È emersa come una proteina di fase acuta cruciale associata all’infiammazione nei disturbi cardiovascolari, tra cui l’insufficienza cardiaca, l’aterosclerosi, le sindromi coronariche acute e le malattie vascolari periferiche. È importante notare che il valore predittivo della PTX3 sembra essere indipendente da altri fattori di rischio, compresi altri marcatori della stessa superfamiglia, come la CRP. Il rapido aumento dei livelli plasmatici di PTX3 durante gli eventi cardiovascolari, conseguenza della rapida sintesi da parte di vari tipi di cellule, supporta l’idea che PTX3 possa fungere da indicatore precoce dell’attivazione delle risposte immunitarie e infiammatorie.

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