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Ocena Estriolu

Ocena Estriolu

Aakifa Ahmad / Md Naushad Alam

67,17 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209598173
67,17 €
IVA incluido
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Wpływ estriolu, trzeciego estrogenu, oceniano pod kątem jego wpływu na model epileptogenezy wywołany pentylenotetrazolem (PTZ) u myszy, a następnie oceniano wywołane rozpalaniem zmiany w funkcjach poznawczych i motorycznych. Rozpalanie indukowano przez traktowanie PTZ raz na 2 dni (25 mg/kg, i.p.) przez 5 tygodni. Rejestrowano nasilenie napadów podczas indukcji rozpalania i procentową częstość występowania zwierząt podpalanych po 5 tygodniach. Funkcję motoryczną oceniano za pomocą miernika siły chwytu, natomiast pamięć przestrzenną oceniano w labiryncie krzyżowym. Estriol (0,005 i 0,01 mg/kg i.p.) skrócił czas indukcji rozpalania z 5 tygodni do 3 i 2 tygodni odpowiednio dla samców i samic myszy oraz zwiększył procentową częstość występowania napadów. Klomifen (0,9 mg/kg i.p.) opóźniał rozwój podpałki i wywoływał działanie przeciwdrgawkowe. Częściowo odwrócił także prodrgawkowe działanie estriolu. W teście siły uścisku i spontanicznym zachowaniu naprzemiennym zaobserwowano znaczny spadek u rozpalonych myszy, który został dodatkowo zmniejszony przez wstępne leczenie estriolem.

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