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O papel dos opióides endógenos no pré-condicionamento isquémico em humanos

O papel dos opióides endógenos no pré-condicionamento isquémico em humanos

Shahid Nazir Muhammad

60,26 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Empresa y gestión
ISBN:
9786202434096
60,26 €
IVA incluido
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Sobre IBD

Acredita-se que os peptídeos opióides endógenos (EOPs) desempenham um papel no pré-condicionamento isquémico (IPC). Utilizando um modelo de lesão por reperfusão isquémica (IR) no antebraço humano, esta investigação avaliou o efeito do antagonista não seletivo dos recetores opióides, naloxona, na proteção pelo IPC. Além disso, as concentrações plasmáticas do opióide endógeno beta-endorfina (β-EP) foram avaliadas durante um estímulo de IPC. O papel do bloqueador dos recetores opióides, naloxona, no IPC em voluntários saudáveis foi determinado. A dilatação mediada pelo fluxo (FMD) da artéria braquial foi medida por ultrassom para determinar a lesão endotelial por IR. Utilizando o ensaio imunoenzimático (ELISA), a β-EP foi quantificada para estabelecer se tem um efeito local para induzir proteção durante a lesão por IR.

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