Inicio > Medicina > Otras ramas de la medicina > Farmacología > Modulation des CB1-Rezeptors bei der Parkinson-Krankheit bei Ratten
Modulation des CB1-Rezeptors bei der Parkinson-Krankheit bei Ratten

Modulation des CB1-Rezeptors bei der Parkinson-Krankheit bei Ratten

Mayank Prabhakar / Puneet Kumar / Rahul Deshmukh

101,39 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209960949
101,39 €
IVA incluido
Disponible

Selecciona una librería:

  • Librería Samer Atenea
  • Kálamo Books
  • Librería Elías (Asturias)
  • Librería Kolima (Madrid)
  • Librería Proteo (Málaga)
Sobre IBD

Kürzlich wurde über die umstrittene Rolle von Cannabinoidrezeptoren in der Pathophysiologie der Parkinson-Krankheit berichtet. In der vorliegenden Studie haben wir die Rolle von CB1-Rezeptoren im motorischen Verhalten untersucht. Zur Erzeugung stabiler motorischer Defizite bei Ratten wurde eine wiederholte intranigrale Infusion (Tag 1, 7, 14) von MPTP durchgeführt. Der CB1-Rezeptoragonist Noladin-Ether und der Antagonist AM 251 wurden den mit MPTP behandelten Ratten allein oder in Kombination verabreicht. Zur Beurteilung des motorischen Verhaltens wurden Tests zur Griffkraft, zur spontanen Bewegungsaktivität und zum Gehen auf einem schmalen Balken durchgeführt. Oxidativer Stress und die Konzentrationen proinflammatorischer Zytokine wurden in Homogenaten des Striatums bestimmt. Die mit MPTP behandelten Ratten zeigten stabile motorische Defizite sowie einen Anstieg des oxidativen Stresses und der Zytokinwerte. AM 251 milderte die MPTP-induzierte motorische Dysfunktion, den oxidativen Stress und die Neuroinflammation bei Ratten. Umgekehrt verstärkte Noladin-Ether die MPTP-vermittelte Neurotoxizität, die durch eine Vorbehandlung mit AM 251 signifikant abgeschwächt wurde.

Artículos relacionados

  • Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential
    Guangshun Wang
    Antimicrobial peptides are key defense molecules adopted by all life forms to prevent infection. They also have other beneficial effects such as boosting immune response, anticancer, and wound healing. The antiviral effects of antimicrobial peptides have laid the foundations for developing new agents to combat seasonal Flu, HIV-1, RSV, Zika, and Ebola. This eBook is constructed...
    Disponible

    67,96 €

  • Mind Maps of Clinical Research Basics
    Amrita Akhouri
    The concepts of Clinical Research have been depicted through mind maps in this book which makes the subject fundamentals very easy to understand and convenient to revise. The chapter on career in clinical research gives an insight into the main job roles currently known in this field along with the focus on how to build preparedness for job interviews. Hence, this book will be ...
    Disponible

    25,42 €

  • Marine Polysaccharides Volume 2
    Paola Laurienzo
    The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailorin...
    Disponible

    75,84 €

  • Marine Polysaccharides Volume 3
    Paola Laurienzo
    The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailorin...
    Disponible

    116,84 €

  • Herbs Used for Hair Growth
    Devi Raman / V. Varalakshmi
    Natural medicine has many benefits, from nourishing the scalp to stimulating hair follicles. Some popular herbs that aid hair growth include rosemary, ginseng, aloe vera, and fenugreek. Each plant has unique properties that help strengthen hair, prevent breakage, and promote growth, healthy growth. Of course, many herbs are popular for their beneficial effects in promoting hair...
    Disponible

    54,32 €

  • Novel Anti-proliferative Agents
    Valentina Onnis
    This Special Issue of Pharmaceuticals presented the recent findings on antiproliferative compounds and highlighted possible routes to discover new drugs used to treat cancer. In this Special Issue, different studies on kinase and methyltransferase-like proteins 3 inhibitors and compounds capable of altering the tumor microenvironment or acting at the mitotic stage of the cell c...

Otros libros del autor

  • Modulation des récepteurs CB1 contre la maladie de Parkinson chez le rat
    Mayank Prabhakar / Puneet Kumar / Rahul Deshmukh
    Récemment, le rôle controversé des récepteurs cannabinoïdes dans la physiopathologie de la maladie de Parkinson a été rapporté. Dans la présente étude, nous avons étudié le rôle des récepteurs CB1 dans le comportement moteur. Des perfusions intranigrales répétées (jours 1, 7 et 14) de MPTP ont été effectuées afin de provoquer des déficits moteurs stables chez les rats. L’agonis...
    Disponible

    102,70 €

  • Modulacja receptora CB1 w leczeniu choroby Parkinsona u szczurów
    Mayank Prabhakar / Puneet Kumar / Rahul Deshmukh
    W ostatnim czasie opisano kontrowersyjną rolę receptorów kannabinoidowych w patofizjologii choroby Parkinsona. W niniejszym badaniu zbadaliśmy rolę receptorów CB1 w zachowaniach motorycznych. W celu wywołania trwałych zaburzeń motorycznych u szczurów przeprowadzono powtarzane wlewy MPTP do jądra czarnego (w 1., 7. i 14. dniu). Agonista receptora CB1, eter noladyny, oraz antagon...
    Disponible

    101,33 €

  • Modulação do recetor CB1 contra a doença de Parkinson em ratos
    Mayank Prabhakar / Puneet Kumar / Rahul Deshmukh
    Recentemente, foi relatado o papel controverso dos recetores canabinóides na fisiopatologia da DP. No presente estudo, investigámos o papel dos recetores CB1 no comportamento motor. Foram realizadas infusões intranigrais repetidas (dias 1, 7 e 14) de MPTP para induzir défices motores estáveis em ratos. O agonista do receptor CB1, éter de noladina, e o antagonista AM 251 foram a...
    Disponible

    101,33 €

  • Modulazione del recettore CB1 contro il morbo di Parkinson nei ratti
    Mayank Prabhakar / Puneet Kumar / Rahul Deshmukh
    Recentemente è stato segnalato il ruolo controverso dei recettori dei cannabinoidi nella fisiopatologia del morbo di Parkinson. Nel presente studio abbiamo esaminato il ruolo dei recettori CB1 nel comportamento motorio. È stata effettuata un’infusione intranigrale ripetuta (giorni 1, 7, 14) di MPTP per indurre deficit motori stabili nei ratti. L’agonista del recettore CB1, Nola...
    Disponible

    101,33 €