Inicio > > Informática: cuestiones generales > Modulating CYP450 Isozymes to Prevent DB[a,l]P-Induced Mammary Cancer
Modulating CYP450 Isozymes to Prevent DB[a,l]P-Induced Mammary Cancer

Modulating CYP450 Isozymes to Prevent DB[a,l]P-Induced Mammary Cancer

Mohammad Kalim Ahmad Khan / Mohd Umar Azeem / Salman Akhtar

72,22 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Informática: cuestiones generales
ISBN:
9786208417154
72,22 €
IVA incluido
Disponible

Selecciona una librería:

  • Librería Samer Atenea
  • Librería Aciertas (Toledo)
  • Kálamo Books
  • Librería Perelló (Valencia)
  • Librería Elías (Asturias)
  • Donde los libros
  • Librería Kolima (Madrid)
  • Librería Proteo (Málaga)
Sobre IBD

Carcinogens transform into electrophilic metabolites, bind to DNA, and cause cancer via metabolic activation, detoxification, angiogenesis, and metastasis. CYP isozymes are therapeutic targets in DBP-induced mammary cancer. LBVS, molecular docking, MD simulations, and in vitro studies have focused on CYP1A1, 1A2, and 1B1. LBVS identified hits, refined using Lipinski’s RO5 and ADMET filters, and docked them using AutoDock4. CHEMBL1, CHEMBL2, and CHEMBL3 showed superior binding affinities to ANF. The stability was confirmed via MD simulations. ADMET filtering yielded nontoxic hits, with ANA8430692 and ANA7923580 exhibiting optimal stability. Molecular dynamics and enzyme inhibition assays validated their potential as CYP inhibitors. Designed analogs ANA6917483, ANA8430692, and ANA6451816 displayed strong binding and interaction patterns, suggesting anticancer potential. This study enhances our understanding of the DBP-induced prevention of mammary cancer.

Artículos relacionados

  • Interview with Jeffery Khoury, Bringing Telemedicine to the People
    Richard G Lowe Jr
    Did you know you can consult with a medical specialist over your smartphone from the comfort of your own home? Imagine speaking to a highly-trained and accredited doctor about whatever is ailing you from virtually anywhere in the world.Thanks to a young entrepreneur named Jeffery Khoury, you can get the advice you need from a pool of medical specialists without waiting in a doc...
    Disponible

    5,82 €

  • IT Consulting Secrets
    Carl A Katz
    This book is for IT consultants of all experience levels and the content is relevant to any IT support business model from managed services (MSP) to break/fix. The author has methodically compiled these strategies and this information from over sixteen years of experience working in the IT support field at the small and medium sized business and enterprise levels. ...
    Disponible

    29,41 €

  • Modeling, Analysis, and Applications in Metaheuristic Computing
    Peng-Yeng Yin
    The engineering and business problems the world faces today have become more impenetrable and unstructured, making the design of a satisfactory problem-specific algorithm nontrivial. Modeling, Analysis, and Applications in Metaheuristic Computing: Advancements and Trends is a collection of the latest developments, models, and applications within the transdisciplinary fields rel...
    Disponible

    256,24 €

  • Knowledge Management and Drivers of Innovation in Services Industries
    Knowledge Management is concerned with all aspects of eliciting, acquiring, modelling, and managing knowledge. Application of knowledge resources successfully helps the organization to deliver creative products and services. Especially in service business, service job experience and information about the customer, as well as the installed site equipment, are key factors to deli...
    Disponible

    229,79 €

  • Current Trends and Future Practices for Digital Literacy and Competence
    Antonio Cartelli
    Being a digital citizen has transformed from a process of familiarizing ones’ self with terminology and techniques to a full-time responsibility in the hands of any who want to stay abreast of the latest technological change in their respective field. Current Trends and Future Practices for Digital Literacy and Competence offers a look at the latest research within digital lite...
    Disponible

    229,55 €

  • Human Rights and Risks in the Digital Era
    Globalization, along with its digital and information communication technology counterparts, including the Internet and cyberspace, may signify a whole new era for human rights, characterized by new tensions, challenges, and risks for human rights, as well as new opportunities. Human Rights and Risks in the Digital Era: Globalization and the Effects of Information Technologies ...
    Disponible

    236,37 €

Otros libros del autor

  • Modulação dos isozimas CYP450 para prevenir o cancro da mama induzido por DB[a,l]P
    Mohammad Kalim Ahmad Khan / Mohd Umar Azeem / Salman Akhtar
    Os carcinogéneos transformam-se em metabolitos electrofílicos, ligam-se ao ADN e causam cancro através da ativação metabólica, desintoxicação, angiogénese e metástases. As isozimas CYP são alvos terapêuticos no cancro da mama induzido por DBP. LBVS, docking molecular, simulações MD e estudos in vitro centraram-se em CYP1A1, 1A2 e 1B1. LBVS identificou hits, refinou-os utilizand...
    Disponible

    72,24 €

  • Modulierung von CYP450-Isozymen zur Verhinderung von DB[a,l]P-induziertem Mammakarzinom
    Mohammad Kalim Ahmad Khan / Mohd Umar Azeem / Salman Akhtar
    Karzinogene wandeln sich in elektrophile Metaboliten um, binden an die DNA und verursachen Krebs durch Stoffwechselaktivierung, Entgiftung, Angiogenese und Metastasierung. CYP-Isoenzyme sind therapeutische Ziele bei DBP-induziertem Brustkrebs. LBVS, molekulares Docking, MD-Simulationen und In-vitro-Studien konzentrierten sich auf CYP1A1, 1A2 und 1B1. LBVS identifizierte Treffer...
    Disponible

    72,22 €

  • Modulation des isoenzymes CYP450 pour prévenir le cancer mammaire induit par le DB[a,l]P
    Mohammad Kalim Ahmad Khan / Mohd Umar Azeem / Salman Akhtar
    Les substances cancérigènes se transforment en métabolites électrophiles, se lient à l’ADN et provoquent le cancer par le biais de l’activation métabolique, de la détoxification, de l’angiogenèse et des métastases. Les isozymes CYP sont des cibles thérapeutiques dans le cancer mammaire induit par le DBP. LBVS, l’amarrage moléculaire, les simulations MD et les études in vitro se...
    Disponible

    72,22 €

  • Modulazione degli isozimi CYP450 per prevenire il cancro mammario indotto da DB[a,l]P
    Mohammad Kalim Ahmad Khan / Mohd Umar Azeem / Salman Akhtar
    Le sostanze cancerogene si trasformano in metaboliti elettrofili, si legano al DNA e causano il cancro attraverso l’attivazione metabolica, la disintossicazione, l’angiogenesi e le metastasi. Gli isozimi CYP sono bersagli terapeutici nel cancro mammario indotto da DBP. L’LBVS, il docking molecolare, le simulazioni MD e gli studi in vitro si sono concentrati sui CYP1A1, 1A2 e 1B...
    Disponible

    72,24 €

  • Modulowanie izoenzymów CYP450 w celu zapobiegania rakowi sutka wywołanemu przez DB[a,l]P
    Mohammad Kalim Ahmad Khan / Mohd Umar Azeem / Salman Akhtar
    Substancje rakotwórcze przekształcają się w elektrofilowe metabolity, wiążą się z DNA i powodują raka poprzez aktywację metaboliczną, detoksykację, angiogenezę i przerzuty. Izozymy CYP są celami terapeutycznymi w raku sutka wywołanym przez DBP. LBVS, dokowanie molekularne, symulacje MD i badania in vitro skupiły się na CYP1A1, 1A2 i 1B1. LBVS zidentyfikował trafienia, udoskonal...
    Disponible

    72,24 €