MODERNES NANO-GEL

MODERNES NANO-GEL

Devi Raman / Sree Sivasakthi A. / Varalakshmi V.

52,01 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786208386092
52,01 €
IVA incluido
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Nanogele sind nichtionische und ionische Nanosysteme, die aus physikalisch oder chemisch vernetzten Polymeren bestehen, die entweder hydrophil, hydrophob oder amphiphil sind. Die Nanogel-bildenden Materialien können auch aus Polysacchariden und Proteinen bestehen, die aufgrund ihrer biologisch abbaubaren, weniger immunogenen Reaktion ausgewählt werden. Diese sind besonders erfolgreich bei der Erhöhung der Nutzlast des Arzneimittels in der Zielregion und der Kontrolle der Neigung aller anderen Nanoträger, den geladenen bioaktiven Stoff auslaufen zu lassen. NGs mit einem Durchmesser zwischen 1 und 1000 nm vereinen die Eigenschaften von Hydrogelen und Nanomaterialien. Ein neuartiger Wirkstofftransporter sollte zwei Hauptmerkmale aufweisen: Er sollte den Wirkstoff mit der gewünschten Geschwindigkeit transportieren und das Medikament erfolgreich an den Zielort bringen. Daher besitzen Nanogele mehrere anspruchsvolle Eigenschaften, die bei der Entwicklung neuer Verabreichungssysteme hilfreich sein können. Ein Nanogel wird in der United States Pharmacopoeia definiert als 'ein halbfestes System, das aus einer Dispersion besteht, die entweder aus kleinen anorganischen Partikeln oder großen organischen Partikeln besteht, die in einer Flüssigkeit enthalten und von dieser durchdrungen sind'.

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