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Integrazione delle fonti dei percorsi

Integrazione delle fonti dei percorsi

Selam T. Bedane

72,02 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630427363
72,02 €
IVA incluido
Disponible

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Sobre IBD

Il rapido sviluppo delle risorse relative alle informazioni sui percorsi biologici aiuta i ricercatori a formulare ipotesi meccanicistiche sui bersagli farmacologici. Esistono numerose fonti aperte e commerciali sui percorsi biologici a disposizione degli scienziati impegnati nella scoperta di nuovi farmaci, ma poiché i percorsi sono astrazioni costruite, vi è una notevole discrepanza tra le diverse fonti. Questo progetto mira all’integrazione delle fonti sui percorsi biologici sulla base della sovrapposizione delle proteine che ne fanno parte e delle interazioni proteina-proteina (PPI). L’obiettivo principale è quantificare la somiglianza tra coppie di vie metaboliche presenti in queste fonti. Ciò è stato realizzato calcolando tre misure di somiglianza: la distanza relativa al contenuto genico, la distanza PPI e la distanza relativa ai nomi delle vie metaboliche. Dopo aver ottenuto i risultati delle tre misure di somiglianza, è stata utilizzata la correlazione di Pearson per verificare se esistesse una relazione tra i risultati.

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