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Intégration de la source du chemin d’accès

Intégration de la source du chemin d’accès

Selam T. Bedane

72,08 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630425536
72,08 €
IVA incluido
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Le développement rapide des ressources d’informations sur les voies métaboliques aide les chercheurs à formuler des hypothèses mécanistiques concernant les cibles thérapeutiques. Il existe de nombreuses sources ouvertes et commerciales de données sur les voies métaboliques à la disposition des chercheurs en découverte de médicaments ; cependant, ces voies étant des abstractions, il existe de nombreuses divergences entre ces sources. Ce projet vise à intégrer ces sources de données sur les voies métaboliques en s’appuyant sur les recoupements entre les protéines qui les composent et les interactions protéine-protéine (IPP). L’objectif principal est de quantifier la similarité entre des paires de voies métaboliques issues de ces sources. Pour ce faire, trois mesures de similarité ont été calculées : la distance de contenu génétique, la distance PPI et la distance entre les noms de voies métaboliques. Une fois ces trois résultats obtenus, la corrélation de Pearson a été utilisée pour déterminer s’il existait une relation entre eux.

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