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Il ruolo degli oppioidi endogeni nel precondizionamento ischemico nell’uomo

Il ruolo degli oppioidi endogeni nel precondizionamento ischemico nell’uomo

Shahid Nazir Muhammad

60,26 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Empresa y gestión
ISBN:
9786202429160
60,26 €
IVA incluido
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Sobre IBD

Si ritiene che i peptidi oppioidi endogeni (EOP) svolgano un ruolo nel precondizionamento ischemico (IPC). Utilizzando un modello di lesione da riperfusione ischemica (IR) dell’avambraccio umano, questa ricerca ha valutato l’effetto dell’antagonista non selettivo dei recettori oppioidi, il naloxone, sulla protezione mediante IPC. Inoltre, sono state valutate le concentrazioni plasmatiche dell’oppioide endogeno beta-endorfina (β-EP) durante uno stimolo IPC. È stato determinato il ruolo del blocco dei recettori oppioidi, naloxone, nell’IPC su volontari sani. La dilatazione mediata dal flusso (FMD) dell’arteria brachiale è stata misurata mediante ultrasuoni per determinare la lesione endoteliale da IR. Utilizzando il test immunoenzimatico (ELISA), la β-EP è stata quantificata per stabilire se ha un effetto locale nell’indurre protezione durante la lesione da IR.

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