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Heparinase und niedermolekulare Heparine als Antitumormittel

Heparinase und niedermolekulare Heparine als Antitumormittel

Alaa N. Mohammed Ali Al-Khfajy / Israa M.S. Abd Ali AL-Kadmy / Sahira Nsayef Muslim

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786208358600
27,55 €
IVA incluido
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Sobre IBD

Heparansulfat und Chondroitinsulfat spielen eine Schlüsselrolle in der extrazellulären Matrix. Heparin ist ein saures Polysaccharid, das durch eine sich wiederholende Disaccharideinheit aus Hexosamin und Uronsäure (L-Iduron- oder D-Glucuronsäure) gekennzeichnet ist, die durch 1-4 Bindungen verbunden sind. Heparin kann nur unter strengen Bedingungen mit Säure hydrolysiert werden, was zu einer beträchtlichen Karamellisierung, insbesondere der Glucoronsäure, und zu einer weitgehenden Aufspaltung des Heparins führt, so dass das Produkt Mono- oder Disaccharide sind, aus denen alle sulfatierten Gruppen entfernt wurden.

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