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Heparinase e heparinas de baixo peso molecular como agentes antitumorais

Heparinase e heparinas de baixo peso molecular como agentes antitumorais

Alaa N. Mohammed Ali Al-Khfajy / Israa M.S. Abd Ali AL-Kadmy / Sahira Nsayef Muslim

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786208358631
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O sulfato de heparano e o sulfato de condroitina desempenham um papel fundamental na matriz extracelular. A heparina é um polissacárido ácido, caracterizado por uma unidade de repetição dissacárida de hexosamina e ácido urónico (ácido L-idurónico ou D-glucurónico) ligados através de ligações 1-4. A heparina é heterogénea devido ao grau variável de modificação dos grupos funcionais na unidade dissacárida. A heparina só pode ser hidrolisada com ácido em condições vigorosas, o que resulta numa caramelização considerável, especialmente do ácido glucorónico, e numa divisão extensa da heparina, pelo que o produto são mono(ou) dissacáridos dos quais todos os grupos sulfatados são removidos.

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