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Extrato da folha de Leptadenia hastata

Extrato da folha de Leptadenia hastata

Idongesit Amos

53,73 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786200822741
53,73 €
IVA incluido
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Leptadenia hastata (Pers.) Decne é uma erva trepadeira que contém látex, possui ação anti-inflamatória e é utilizada na medicina tradicional para cicatrizar feridas e tratar sintomas reumáticos e doenças de pele, como furúnculos. Isso motivou a presente investigação preliminar sobre os seus efeitos na migração de leucócitos, para servir de base para uma análise mais aprofundada dos possíveis mecanismos moleculares e de sinalização subjacentes à sua ação anti-inflamatória. A compreensão dos efeitos dos extratos das folhas de Leptadenia hastata nos leucócitos, que normalmente abrigam muitos mediadores solúveis locais da inflamação, pode ser particularmente útil na descoberta de alvos moleculares para o desenvolvimento de novos medicamentos anti-inflamatórios. O presente estudo demonstrou que a ação anti-inflamatória da folha de Leptadenia hastata pode ser parcialmente mediada pela inibição dos neutrófilos. Assim, pode ser seguro sugerir que a folha de Leptadenia hastata inibe a libertação de ácido araquidónico das membranas, a expressão de moléculas de adesão celular complementares e/ou a expressão de fatores quimiotáticos/quimioatractantes que podem ser cruciais para o recrutamento e transmigração de neutrófilos.

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