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Extrait de feuille de Leptadenia hastata

Extrait de feuille de Leptadenia hastata

Idongesit Amos

53,73 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786200822727
53,73 €
IVA incluido
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Leptadenia hastata (Pers.) Decne est une plante grimpante contenant du latex qui possède des propriétés anti-inflammatoires et est utilisée en médecine traditionnelle pour la cicatrisation des plaies et le traitement des symptômes rhumatismaux et des affections cutanées telles que les furoncles. Cela a encouragé la présente étude préliminaire sur ses effets sur la migration des leucocytes, afin de servir de base à une analyse plus approfondie des mécanismes moléculaires et de signalisation possibles qui sous-tendent son action anti-inflammatoire. Une compréhension des effets des extraits de feuilles de Leptadenia hastata sur les leucocytes, qui hébergent normalement de nombreux médiateurs inflammatoires solubles locaux, peut être particulièrement utile pour découvrir des cibles moléculaires pour le développement de nouveaux médicaments anti-inflammatoires. La présente étude a montré que l’action anti-inflammatoire de la feuille de Leptadenia hastata pourrait être en partie médiée par l’inhibition des neutrophiles. On peut donc supposer sans risque que la feuille de Leptadenia hastata inhibe la libération d’acide arachidonique par les membranes, l’expression de molécules d’adhésion cellulaire complémentaires et/ou l’expression de facteurs chimiotactiques/chimioattractants qui pourraient être essentiels au recrutement et à la transmigration des neutrophiles.

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