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Expression von miR-21-5p bei Fehlgeburten

Expression von miR-21-5p bei Fehlgeburten

Salima Ferchichi / Sarra Souayah / Wael Bahia

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786208158705
76,28 €
IVA incluido
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Sobre IBD

Der rezidivierende Spontanabort (RSA) stellt eine große klinische Herausforderung dar, wobei die Ätiologie noch weitgehend ungeklärt ist. Unsere Studie konzentriert sich auf die Assoziation zwischen drei Polymorphismen des NFκB1-Gens und SVB in einer Fall-Kontroll-Kohorte der tunesischen Bevölkerung. Die Ergebnisse zeigen eine signifikante Korrelation, insbesondere für rs28362491, mit deutlichen Unterschieden in den allelischen und genotypischen Häufigkeiten zwischen den Gruppen. Die haplotypische Analyse unterstreicht die Beteiligung bestimmter Haplotypen, insbesondere TAG und AGG, an SVB. Die Untersuchung der differentiellen Expression von hsa-miR-21-5p mit NFκB1 und IL-6 mittels qPCR lässt jedoch aufgrund der begrenzten Stichproben und der seltenen Fälle von Frauen, die vier oder mehr aufeinanderfolgende Spontanaborte hatten, ohne Kinder zu bekommen, keine definitiven Schlussfolgerungen zu. Diese Ergebnisse unterstreichen die Bedeutung künftiger Forschungsarbeiten, um die dem SVB zugrunde liegenden Mechanismen aufzuklären und wirksame Präventions- und Behandlungsstrategien zu entwickeln.

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