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Espressione di miR-21-5p negli aborti spontanei

Espressione di miR-21-5p negli aborti spontanei

Salima Ferchichi / Sarra Souayah / Wael Bahia

76,22 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786208158736
76,22 €
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Sobre IBD

L’aborto spontaneo ricorrente (RSA) rappresenta una sfida clinica importante, con un’eziologia che rimane in gran parte inspiegabile. Il nostro studio si concentra sull’associazione tra tre polimorfismi del gene NFκB1 e RSA in una coorte caso-controllo della popolazione tunisina. I risultati indicano una correlazione significativa, in particolare per l’rs28362491, con notevoli differenze nelle frequenze alleliche e genotipiche tra i gruppi. L’analisi aplotipica ha evidenziato il coinvolgimento di alcuni aplotipi, in particolare TAG e AGG, nell’ASR. Tuttavia, lo studio dell’espressione differenziale di hsa-miR-21-5p con NFκB1 e IL-6 mediante qPCR non consente di trarre conclusioni definitive, a causa della limitazione dei campioni e della rarità dei casi di donne che hanno subito quattro o più aborti spontanei successivi senza avere figli. Questi risultati sottolineano l’importanza di future ricerche per chiarire i meccanismi alla base della RSA e sviluppare strategie di prevenzione e trattamento efficaci.

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