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Effetti protettivi della Digera muricata (L.) Mart contro la tossicità epatica

Effetti protettivi della Digera muricata (L.) Mart contro la tossicità epatica

Amtul Bari Tabinda Akhtar / Muhammad Afzaal / Muhammad Rasheed Khan

41,57 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208632335
41,57 €
IVA incluido
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Questo esperimento è stato condotto per determinare gli effetti protettivi dell’estratto metanolico di Digera muricata (L.) Mart. sulle lesioni indotte dall’acrilammide nei tessuti epatici dei ratti a livello istologico e biochimico. Quarantotto femmine sane di ratto albino, del peso di 190-200 g, sono state fornite dalla Animal House del National Institute of Health (NIH) di Islamabad e sono state mantenute presso la Primate Facility dell’Università Quaid-i-Azam di Islamabad. Questi ratti sono stati divisi in otto gruppi con sei ratti per ogni gruppo. Il gruppo I è rimasto di controllo, mentre il gruppo II è stato trattato con DMSO 5,0 ml/kg B.w. (peso corporeo) per via orale una volta al giorno per cinque settimane. Al gruppo III sono stati somministrati 200 mg/kg B.w. di estratto metanolico di Digera muricata disciolto in DMSO una volta al giorno per cinque settimane. Il resto dei ratti è stato diviso in cinque gruppi e trattato con una soluzione acquosa di acrilammide 6 mg/kg p.c. per via intraparetale una volta al giorno per due settimane. Il gruppo IV è stato sacrificato dopo il trattamento con acrilammide per raccogliere il siero e il fegato. Il gruppo V è rimasto tale per il resto dell’esperimento. Ai gruppi VI, VII e VIII sono stati somministrati 100, 150 e 200 mg/kg di estratto metanolico di Digera muricata.

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