Inicio > Matemáticas y ciencia > Biologia, ciencias de la vida > Efeitos protectores da Digera muricata (L.) Mart. contra a toxicidade hepática
Efeitos protectores da Digera muricata (L.) Mart. contra a toxicidade hepática

Efeitos protectores da Digera muricata (L.) Mart. contra a toxicidade hepática

Amtul Bari Tabinda Akhtar / Muhammad Afzaal / Muhammad Rasheed Khan

41,63 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208632571
41,63 €
IVA incluido
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Esta experiência foi realizada para determinar os efeitos protectores do extrato metanólico de Digera muricata ( L.) Mart. nas lesões induzidas pela acrilamida nos tecidos hepáticos de ratos a nível histológico e bioquímico. Quarenta e oito ratos albinos fêmeas saudáveis, com um peso de 190-200 g, foram fornecidos pelo Biotério do Instituto Nacional de Saúde (NIH) de Islamabad e mantidos nas instalações para primatas da Universidade Quaid-i-Azam, em Islamabad. Estes ratos foram divididos em oito grupos, com seis ratos em cada grupo. O grupo I serviu de controlo, enquanto o grupo II foi tratado com DMSO 5,0 ml/kg de peso corporal, por via oral, uma vez por dia, durante cinco semanas. O grupo III recebeu 200 mg/kg B.w. de extrato metanólico de Digera muricata dissolvido em DMSO uma vez por dia durante cinco semanas. Os restantes ratos foram divididos em cinco grupos e tratados com uma solução aquosa de acrilamida 6 mg/kg B.w. por via intraparetoneal uma vez por dia durante duas semanas. O grupo IV foi sacrificado após o tratamento com acrilamida para recolha do soro e do fígado. O grupo V permaneceu sem tratamento durante o resto da experiência. Aos grupos VI, VII e VIII foram administrados 100, 150 e 200 mg/kg de extrato metanólico de Digera muricata.

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