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Chemia izoksazolu

Chemia izoksazolu

Mayuri Ravindra Joshi / Nilima Narendra Dixit

65,43 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Química orgánica
ISBN:
9786209002557
65,43 €
IVA incluido
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Chemia izoksazolu jest związana z nazwiskiem Ludwiga Claisena, który odkrył 3-fenylo-5-izoksazolon, przeprowadzając reakcję estru benzoiloctowego z hydroksyloaminą. 4-izoksazolonom, które są tautomeryczne z 4-hydroksy-izoksazolami, poświęcono niewiele uwagi. Uznanie aktywności farmakologicznej niektórych pochodnych izoksazolu, takich jak Cycliton, dialkiloamid izoksazolowego kwasu karboksylowego stosowany jako analeptyk2-4 i Gantrisin, lek sulfonamidowy z aminoizoksazolu5-8, przyczyniło się do rozwoju chemii izoksazoli. Antybiotyk, cykloseryna9,10 (lub oksamycyna), prosta pochodna 3-izoksazolidonu, wzbudziła nowe zainteresowanie w tej dziedzinie.

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