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Autoanticorpi associati a malattie epatiche autoimmuni

Autoanticorpi associati a malattie epatiche autoimmuni

Sabrina MEJDOUB

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208801946
60,13 €
IVA incluido
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Il test degli autoanticorpi (auto-Ab) nel siero è utile per diagnosticare le epatopatie autoimmuni (AIH). Questo test viene eseguito in immunofluorescenza indiretta (IFI) su un triplo substrato e può essere integrato da altre tecniche. Delle 167 richieste di analisi per gli auto-Ac associati all’HPAI, l’IFI a triplo substrato è risultato positivo in 19 casi (11,4%), con Ac anti-mitocondri rilevati in 14 casi (8,4%) e Ac anti-muscolo liscio rilevati in 5 casi (3%). L’IFI su VSM47 ha identificato anticorpi anti-actina F in 3/5 casi. L’immunodot ha confermato la positività degli Ac anti-mitocondri nei 14 casi rilevati dall’IFI, con o senza identificazione di altri auto-Ac associati. Inoltre, l’immunodot, effettuato nonostante la negatività dell’IFI in 43 casi, è risultato positivo in 13 casi/43. Quindi, almeno un Ac è risultato positivo in 32/167 pazienti (19,2%), 17 dei quali presentavano un profilo sierologico a favore della cirrosi biliare primaria e 9 un profilo a favore dell’epatite autoimmune di tipo 1. La positività di questi auto-Ac deve essere interpretata in base al contesto clinico. La biopsia epatica può essere indicata per confermare la diagnosi di una delle entità HPAI.

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