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Approccio alla somministrazione vaginale di farmaci per la terapia antimicotica

Approccio alla somministrazione vaginale di farmaci per la terapia antimicotica

Ammar Ali Saleh Jaber / M. Aamir Mirza / Zeenat Iqbal

67,59 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786208300661
67,59 €
IVA incluido
Disponible

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La somministrazione efficiente di farmaci nella cavità vaginale è spesso una sfida a causa delle sue peculiari variazioni fisiologiche, tra cui le grandi differenze di pH. Tenendo conto di questa caratteristica del sito target, il presente lavoro è stato finalizzato allo sviluppo di strategie di formulazione in grado di superare questo problema e di veicolare con successo molecole come la Ciclopirox olamina attraverso gli SLN. Le SLN ottimizzate sono state selezionate per un ulteriore sviluppo. Quando è stato valutato in vivo, non ha mostrato alcun potenziale irritativo, nonostante un’apprezzabile bioadesione. È stata inoltre osservata una notevole riduzione delle CFU quando è stato valutato il modello di infezione nel ratto. Lo studio proposto definisce quindi le sfide per lo sviluppo di un sistema di formulazione adatto a superare le barriere di somministrazione del sito vaginale.

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Otros libros del autor

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