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Analiza metforminy w osoczu ludzkim przy użyciu HPLC

Analiza metforminy w osoczu ludzkim przy użyciu HPLC

Aya Alabdali / Monther Faisal Mahdi

60,52 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208999186
60,52 €
IVA incluido
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Chlorowodorek metforminy jest najczęściej stosowanym doustnym lekiem hipoglikemicznym. Stężenie metforminy we krwi należy regularnie mierzyć u pacjentów z cukrzycą, aby zapobiec toksyczności metforminy i określić przestrzeganie zaleceń dotyczących przyjmowania leku. Do pobrania próbek do analizy metforminy wykorzystano technikę kart z wysuszoną krwią (DBS). Opracowano prostą metodę HPLC do ilościowego oznaczania metforminy w osoczu ludzkim. Procedura obejmuje fazę stacjonarną C-18 z użyciem 34% acetonitrylu i 66% fazy wodnej. Faza wodna zawierała 10 mM fosforanu potasu (KH2PO4) i 10 mM dodecylosiarczanu sodu (SDS), pH wynosiło 5,3, a detektor UV był ustawiony na 234 nm. Metformina została pomyślnie wyekstrahowana z wysuszonej plamki krwi za pomocą niedrogiej, prostej, jednoetapowej ekstrakcji cieczą przy użyciu 100% metanolu przez 2 minuty. Wymagano jedynie 10 μl krwi. Średni odzysk metforminy z DBS wyniósł 95%.

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