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Análise in vitro e in silico das interações dos derivados da benzoxazina com alvos biológicos fundamentais

Análise in vitro e in silico das interações dos derivados da benzoxazina com alvos biológicos fundamentais

Atika Yanina / Hanane Mouada / Meriem Chebane

66,66 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Química
ISBN:
9786209558801
66,66 €
IVA incluido
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Dois derivados de benzoxazina (3a e 3b) interagiram com alvos biológicos para estudar os seus efeitos antioxidantes e anticancerígenos. A substituição por um átomo de hidrogénio permitiu ao composto 3a inibir os radicais DPPH mais eficazmente do que o ácido ascórbico , com um valor EC50 mais baixo. Investigações in silico mostraram que os compostos se ligavamespontaneamente à glutationa peroxidase 7 através de ligações de hidrogénio convencionais, sugerindo que ligações de hidrogénio convencionais, o que sugere que podem neutralizar as espécies reactivas de oxigénio. O composto 3a pode induzir a conformação do ADN de cadeia simples in vitro. Energias de ligação semelhantes aos resultados in vitro sugerem mecanismos de interação específicos e menores nas experiências de acoplamento. Um aumento da absorvância a 280 nm e a ligação eletrostática dos compostos à BSA sugerem o seu potencial anticancerígeno.potencial anticancerígeno. Estes resultados permitem esclarecer os processos farmacológicos e o potencial medicinal dos derivados da benzoxazina.Palavras chave: Derivados de benzoxazina, atividade antioxidante, potencial anti-tumoral, ADN, BSA, docking molecular.

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