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α- Attività inibitoria dell’amilasi della basella rubra

α- Attività inibitoria dell’amilasi della basella rubra

B. Samuel Thavamani

44,83 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786208131463
44,83 €
IVA incluido
Disponible

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Il diabete mellito è un disturbo metabolico comune che aumenta il livello di glucosio postprandiale, il che può portare a danni multipli agli organi e al rischio di malattie cardiovascolari, che sono la causa più comune di morte tra le persone con diabete. La gestione del livello di glucosio nel sangue è fondamentale per il trattamento precoce del diabete mellito e delle sue complicanze. Il brusco aumento del livello di glucosio nel sangue dopo l’assunzione di cibo dall’intestino è favorito dagli enzimi α-amilasi che scindono i carboidrati in zuccheri semplici assorbibili. Gli inibitori enzimatici sintetici, come acarbose, miglitolo e voglibose, sono utili come farmaci ipoglicemizzanti orali per il controllo dell’iperglicemia postprandiale, soprattutto nei pazienti con diabete di tipo II. Questi inibitori ritardano la digestione dei carboidrati e prolungano il tempo di assorbimento del glucosio nell’intestino. L’uso cronico di questi inibitori, insieme ad altri farmaci antidiabetici, provoca effetti collaterali a livello gastrointestinale come disturbi addominali, flatulenza e diarrea. Diverse piante sono state identificate come potenziali fonti di farmaci nel sistema di medicina indiano per il trattamento del diabete. Sulla base di una revisione della letteratura e della presente indagine fitochimica, è emerso che

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