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Zespół metaboliczny

Zespół metaboliczny

Imane BOURAGBA / Mustapha Diaf

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208987022
64,18 €
IVA incluido
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Zespół metaboliczny to grupa schorzeń, które zwiększają ryzyko chorób serca, udaru mózgu i cukrzycy. Charakteryzuje się otyłością brzuszną, nadciśnieniem tętniczym, hiperglikemią i dyslipidemią, wymagając co najmniej trzech kryteriów diagnostycznych: obwód talii >102 cm u mężczyzn lub >88 cm u kobiet, trójglicerydy ≥1,7 mmol/l, niski poziom HDL, nadciśnienie tętnicze (≥130/85 mmHg) i stężenie glukozy we krwi na czczo ≥1,1 g/l. Czynniki przyczyniające się do jej rozwoju obejmują otyłość, siedzący tryb życia, genetykę, wiek, pochodzenie etniczne, zmiany hormonalne, dietę, palenie tytoniu i spożywanie alkoholu. Ma złożoną patofizjologię obejmującą insulinooporność (IR) związaną z nadmiarem trzewnej tkanki tłuszczowej, która uwalnia cytokiny prozapalne i wolne kwasy tłuszczowe, zaostrzając IR i stan zapalny. Insulinooporność zaburza również metabolizm lipidów, prowadząc do dyslipidemii i może upośledzać funkcję śródbłonka, sprzyjając miażdżycy. Zwiększa to ryzyko choroby wieńcowej, udaru mózgu, choroby tętnic obwodowych, niewydolności serca i chorób nerek.

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