Librería Samer Atenea
Librería Aciertas (Toledo)
Kálamo Books
Librería Perelló (Valencia)
Librería Elías (Asturias)
Donde los libros
Librería Kolima (Madrid)
Librería Proteo (Málaga)
Asthma in children is the most common respiratory disease worldwide. It is a major cause of morbidity and mortality. An accurate assessment of its prevalence has been hampered by the heterogeneity of asthma definitions. It has been described that vitamin D possesses an immunomodulatory effect via its receptor (VDR) and 1-alpha-hydroxylase, which are present in T and B lymphocytes, macrophages and antigen-presenting cells. Thus, 25 hydroxy-vitamin D (25 OH D) reduces the proliferation of T lymphocytes (particularly Thelper-1 [Th1] and Th17 lymphocytes) and the production of certain 'pro-inflammatory' cytokines (particularly Il-2, Il-6 and IFN-γ), and it has also been described that the vitamin reduces mainly viral respiratory infections and improves lung function. The interaction between asthma and vitamin D has been studied over the past two decades. This interaction is multi-faceted and has potential clinical implications for asthmatic patients, affecting disease severity, control and prognosis.
