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Vettori colloidali per il rilascio di proteine a livello mucosale

Vettori colloidali per il rilascio di proteine a livello mucosale

Akhlesh Kumar Jain

49,93 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786207205318

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La somministrazione di farmaci macromolecolari per via transmucosale è stata un compito interessante ma impegnativo per i ricercatori fin dalla scoperta del primo peptide terapeutico decenni fa, l’insulina, nel 1922. La scelta di un sistema di trasporto appropriato è un aspetto molto critico per una terapia sicura, efficace e conveniente attraverso la somministrazione transmucosale di macromolecole. Le complessità fisiochimiche e le proprietà biologiche dei bioattivi macromolecolari richiedono un sistema di trasporto efficiente che affronti questioni come le dimensioni molecolari, la stabilità conformazionale, l’emivita biologica, l’immunogenicità, i requisiti di dose, i complessi meccanismi di controllo a feedback, la suscettibilità alla rottura in ambienti fisici e biologici; i requisiti per i meccanismi di trasporto specializzati attraverso la membrana biologica sono debitamente considerati.

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Otros libros del autor

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