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Validation d’une méthode de dosage de ciclosporine A dans les collyres

Validation d’une méthode de dosage de ciclosporine A dans les collyres

Chema Drira / Ikram Fazaa / Sarra AOUIDA

64,56 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209088117
64,56 €
IVA incluido
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Sobre IBD

La ciclosporine, difficilement soluble dans l’eau, a été formulée en collyre par dilution dans un véhicule aqueux à base de povidone, sans conservateur.Une méthode de dosage par HPLC a été développée (colonne C18, phase mobile acétonitrile/méthanol/eau) et validée.Elle s’est révélée spécifique, linéaire et reproductible avec des variations et biais faibles. Le profil d’exactitude a confirmé la fiabilité des résultats dans les limites d’acceptabilité. Le contrôle microbiologique était satisfaisant.Cette préparation est simple, fiable et réalisable en pharmacie hospitalière.

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