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Uwalnianie i przenikanie produktów transdermalnych

Uwalnianie i przenikanie produktów transdermalnych

Fabíola Silva Garcia Praça

57,90 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208626730
57,90 €
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Sobre IBD

Transdermalne uwalnianie leków ma kilka zalet terapeutycznych w porównaniu z podawaniem doustnym lub pozajelitowym. Do tej pory w Farmakopei Brazylijskiej nie określono metody przeprowadzania testów uwalniania leku z plastrów transdermalnych. Inne oficjalne kompendia, takie jak Farmakopea Amerykańska, Brytyjska i Europejska, opisują aparaturę z łopatkami na dysku, obracającym się cylindrem i wzajemnym podparciem. Literatura opisuje obecnie różne typy komórek dyfuzyjnych do uwalniania przezskórnego, z których najczęściej stosowana jest komórka dyfuzyjna Franza. Celem tego badania było ustalenie kryteriów najbardziej odpowiedniego wyboru sprzętu i metodologii „in vitro' do oceny przezskórnego uwalniania leków. Wyniki tego badania są ważnym narzędziem do dyskusji na temat testów równoważności farmaceutycznej i kontroli jakości leków przezskórnych, a także zrozumienia możliwych błędów procesowych. Mogą one również dostarczyć danych do protokołów wskazań dla Farmakopei Brazylijskiej i badań naukowych nad systemami dostarczania leków.

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