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Toksykologiczna patologia środków antykoncepcyjnych u kobiet

Toksykologiczna patologia środków antykoncepcyjnych u kobiet

Bahaa Al-Sereah / Mohammed Hassan / Saleh Majeed

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209267314
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Niniejszy projekt badawczy dotyczył środków antykoncepcyjnych, a jako model eksperymentalny wykorzystano szczury. Badanie trwało sześć miesięcy i polegało na doustnym podawaniu tabletek antykoncepcyjnych LD, z których każda zawierała: 0,15 mg lewonorgestrelu i 0,03 mg etynyloestradiolu. Badanie przeprowadzono na dwóch grupach po osiem samców i osiem samic szczurów. Pierwsza grupa stanowiła grupę kontrolną niepoddaną leczeniu, a druga grupa była poddana leczeniu. Przez pierwsze trzy miesiące grupie poddanej leczeniu podawano doustnie jedną tabletkę rozpuszczoną w wodzie każdemu szczurowi, a w ostatnich trzech miesiącach dawkę zwiększono do jednej tabletki dla każdego zwierzęcia. Zmiany histopatologiczne obejmowały zahamowanie spermatogenezy w jądrach u samców i zanik jajników u samic, a ponadto zmiany histopatologiczne w wątrobie, nerkach, sercu, płucach, mięśniach szkieletowych, skórze, najądrzach i prostacie.

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