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The Hypothalamic-Pituitary-Adrenal (HPA) axis in the face of envenomation

The Hypothalamic-Pituitary-Adrenal (HPA) axis in the face of envenomation

Fares Daachi / Sonia Adi-Bessalem

117,05 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208905170
117,05 €
IVA incluido
Disponible

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Thehypothalamic-pituitary-adrenal(HPA)axis is a key player in the interaction between the neuroendocrine and immune systems. This study explores the impact ofAndroctonus australis hector(Aah) venom on HPA axis activation, as a function of day-night phases. Using an experimental approach, we analyze the inflammatory responses and oxidative damage induced by envenomation, highlighting the modulation exerted by corticosterone. Increased serum levels of ACTH and corticosterone indicate increased activation of the HPA, most marked during the active phase. At the same time, venom causes oxidative damage and cardio-hepatic alterations, amplified by excessive production of reactive oxygen and nitrogen species. The involvement of corticosterone in these disturbances was assessed using a dexamethasone suppression test. These results highlight an inflammatory and metabolic response modulated by circadian rhythms, underlining the importance of the HPA in the management of toxic stress.

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