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Test diagnostici per la rabbia e studi sull’espressione delle citochine nei topi

Test diagnostici per la rabbia e studi sull’espressione delle citochine nei topi

Byregowda S.M. / Satish Mundas / Suguna Rao

131,24 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Empresa y gestión
ISBN:
9786630326901
131,24 €
IVA incluido
Disponible

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Il presente studio è stato condotto con l’obiettivo di valutare la specificità di diversi test diagnostici in casi clinici di rabbia, di valutare le alterazioni patomorfologiche nella rabbia indotta sperimentalmente nei topi con il virus fissato e il virus di Street e di determinare l’espressione delle citochine proinfiammatorie e la loro relazione con l’eliminazione del virus dal tessuto cerebrale nei topi. Sono stati raccolti complessivamente 114 campioni cerebrali di casi sospetti di rabbia, che sono stati sottoposti a colorazione di Seller, FAT, dRIT e RT-PCR per la diagnosi della rabbia. Di questi, 81 campioni sono risultati positivi ai diversi test, con un’incidenza complessiva della rabbia pari al 71,05%. I risultati dell’esame microscopico diretto alla ricerca dei corpi di Negri mediante la tecnica di colorazione di Seller hanno rilevato la presenza di corpi di Negri in 64 campioni cerebrali su 114 provenienti da diverse specie, con una positività del 56,14%, mentre il FAT e il dRIT hanno rilevato 77 casi (67,54%) positivi alla rabbia. I campioni positivi e negativi ottenuti con la colorazione di Seller, il test FAT e il test dRIT sono stati ulteriormente confermati mediante la RT-PCR convenzionale, che ha rilevato la rabbia in 81 casi.

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